New PDF release: Androgen Excess Disorders in Women: Polycystic Ovary

By Ricardo Azziz (auth.), Ricardo Azziz MD, MPH, MBA, John E. Nestler MD, Didier Dewailly MD (eds.)

ISBN-10: 1588296636

ISBN-13: 9781588296634

ISBN-10: 1597451797

ISBN-13: 9781597451796

The box of androgen extra issues has complex considerably because the unique e-book of this publication. The Androgen extra Society (AES) was once based to assemble investigators within the box. a greater knowing of the screening, development, and molecular genetics of nonclassic adrenal hyperplasia (NCAH) has more desirable the medical care and diagnostic accuracy of those sufferers. New standards for the analysis of the polycystic ovary syndrome (PCOS) have been proposed in Rotterdam, standards that experience led to controversy and, confidently, initiation of recent stories. The organization of insulin resistance with PCOS has been bolstered, and the function of metformin in tre- ing the infertility of the PCOS has been demonstrated. hazards for diabetes and, extra cont- versially, heart problems in girls with PCOS have got big research. Our knowing of the epidemiology and monetary impression of those issues has increased, emphasizing their serious significance. those are yet a couple of highlights of the way the terrain has replaced in a comparatively short time period. according to those advances, the name of this e-book has been revised to mirror the becoming significance of PCOS because the so much usual androgen extra sickness in girls, and arguably, because the one who may need the main severe antagonistic effects for common health and wellbeing. There are fewer chapters to supply a extra targeted elucidation of the world. numerous chapters have been penned via new (and younger) authors who're carrying out state of the art learn within the field.

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Suzuki T, Sasano H, Takeyama J, et al. Developmental changes in steroidogenic enzymes in human postnatal adrenal cortex: immunohistochemical studies. Clin Endocrinol 2000;53:739–747. 73. Auchus RJ, Geller DH, Lee TC, Miller WL. The regulation of human P450c17 activity: relationship to premature adrenarche, insulin resistance and the polycystic ovary syndrome. Trends Endocrinol Metab 1998;9:47–50. 74. Ibañez L, Potau N, Virdis R, et al. Postpubertal outcome in girls diagnosed of premature pubarche during childhood: Increased frequency of functional ovaian hyperandrogenism.

Nat Genet 2004;36:228–230. 37. Arlt W, Walker EA, Draper N, et al. Congenital adrenal hyperplasia caused by mutant P450 oxidoreductase and human androgen synthesis: analytical study. Lancet 2004;363:2128–2135. 38. Adachi M, Tachibana K, Asakura Y, Yamamoto T, Hanaki K, Oka A. Compound heterozygous mutations of cytochrome P450 oxidoreductase gene (POR) in two patients with Antley-Bixler syndrome. Am J Med Genet 2004;128A:333–339. 39. Fukami M, Horikawa R, Nagai T, et al. POR (P450 oxidoreductase) mutations and Antley-Bixler syndrome with abnormal genitalia and/or impaired steroidogenesis: molecular and clinical studies in 10 patients.

Geller DH, Auchus RJ, Miller WL. P450c17 mutations R347H and R358Q selectively disrupt 17,20-lyase activity by disrupting interactions with P450 oxidoreductase and cytochrome b5. Mol Endocrinol 1999;13:167–175. 34. Pandey AV, Mellon SH, Miller WL. Protein phosphatase 2A and phosphoprotein SET regulate androgen production by P450c17. J Biol Chem 2003;278:2837–2844. 35. Miller WL. The molecular basis of adrenarche: A hypothesis. Acta Pediatr 1999;88 (Suppl 433):60–66. 36. Flück CE, Tajima T, Pandey AV, et al.

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Androgen Excess Disorders in Women: Polycystic Ovary Syndrome and Other Disorders by Ricardo Azziz (auth.), Ricardo Azziz MD, MPH, MBA, John E. Nestler MD, Didier Dewailly MD (eds.)


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