James Sidney Lucas's Austro-Hungarian infantry, 1914-1918 PDF

By James Sidney Lucas

ISBN-10: 0855240962

ISBN-13: 9780855240967

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1978a). 2. Extrapolation of the Model to Inbred Strains Since outbred CD-l mice were not histocompatible and therefore not suitable for adoptive transfer studies, ROSSINI et al. (1977) compared MSZ susceptibility among males of various inbred mouse strains. Only C57BL/KsJ (BKs) exhibited the high sensitivity to MSZ induction of severe insulitis and hyperglycemia characteristic of CD-l males. Interestingly, prenecrotic {3 cells in islets of MSZtreated BKs males also showed induction of an endogenous {3 cell retroviral genome, that of an intracisternal type A particle [lAP (ApPEL et al.

A similar experiment by TOCHINO (unpublished observation) showed that the removal of sex organs at 10 weeks of age did not affect the incidence of diabetes in either sex. However, when testosterone was administered to these mice, no animals from either sex developed diabetes, while when estradiol was given, overt diabetes appeared in mice of both sexes. These results directly demonstrate that sex hormones regulate the development of diabetes in NOD mice. It would be interesting to know the effects of sex hormones on the immunological responses.

L. Wilson and E. H. Leiter injections were administered once daily for 5 consecutive days (experiment days 1-5). Progressively severe glucose intolerance was noted at 7 days and by experiment day 31, a permanent, severe diabetic condition was produced. Heavy insulitis and disruption of islet cytoarchitecture was noted by experiment day 11. Preceding the arrival of the inflammatory cells was the induction in {3 cells of endogenous retroviruses, which were morphologically and immunocytochemically identified as type C (ApPEL et al.

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Austro-Hungarian infantry, 1914-1918 by James Sidney Lucas

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